TKI258 treatment induces dose-dependent inhibition of phosphorylation of ZNF198-FGFR1, BCR-FGFR1, ERK, and STAT5. Phosphorylation of ERK, STAT5, and the BCR-FGFR1 and ZNF198-FGFR1 fusion proteins after exposure to TKI258 was assessed by Western blotting.