Figure 1.
Figure 1. Serum EPO and erythroid progenitors in Mx1-Cre, KrasG12D mice. (A) Serum EPO and hemoglobin (Hb) concentrations in Mx1-Cre, KrasG12D mice (open symbols) and wild-type (wt) littermates (closed symbols); data are pooled from F1 (n = 18; circles) and C57BL/6 (n = 9; squares) mice. (B) Total CFU-Es recovered from bone marrow (2 femurs and 2 tibias) and spleens of Mx1-Cre, KrasG12D mice (□) and wild-type littermates (▪) shown as mean ± SEM. (C) Total BFU-Es are enumerated as in panel B. (D) EPO dose-response of BFU-Es derived from C57BL/6 bone marrow, showing mean ± SEM from 3 independent experiments. (E,F) Photomicrographs of typical BFU-Es from bone marrow cultured with 50 ng/mL EPO for 7 days (bar represents 500 μm).

Serum EPO and erythroid progenitors in Mx1-Cre, KrasG12D mice. (A) Serum EPO and hemoglobin (Hb) concentrations in Mx1-Cre, KrasG12D mice (open symbols) and wild-type (wt) littermates (closed symbols); data are pooled from F1 (n = 18; circles) and C57BL/6 (n = 9; squares) mice. (B) Total CFU-Es recovered from bone marrow (2 femurs and 2 tibias) and spleens of Mx1-Cre, KrasG12D mice (□) and wild-type littermates (▪) shown as mean ± SEM. (C) Total BFU-Es are enumerated as in panel B. (D) EPO dose-response of BFU-Es derived from C57BL/6 bone marrow, showing mean ± SEM from 3 independent experiments. (E,F) Photomicrographs of typical BFU-Es from bone marrow cultured with 50 ng/mL EPO for 7 days (bar represents 500 μm).

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