TSSC6^–/– mice display features of unstable hemostasis in vivo. Hemostasis in 6- to 8-week-old mice was assessed using an in vivo tail-bleeding assay. (A) Time taken for cessation of bleeding for wild-type and TSSC6^–/– mice (n = 20). P < .05 (Student t test). (B) Volume of blood lost during tail-bleeding time for wild-type and TSSC6^–/– mice (n = 20). P < .05 (Student t test). (C) Rebleeding occurrences in wild-type and TSSC6^–/– mice (n = 20). P < .005 (Student t test). Errors bars indicate SEM.