TSSC6^–/– platelets display normal platelet aggregation responses to PAR-4, ADP, type 1 collagen, and calcium ionophore. Aggregation responses of PRP (platelet count adjusted to 100 × 10⁹/L) for wild-type and TSSC6^–/– mice were determined following activation with different concentrations of various agonists: PAR-4 agonist peptide (125-250 μM), ADP (5-20 μM), type 1 collagen (5-20 μg/mL), and calcium ionophore (2.5-10 μg/mL), respectively.