Figure 4.
![Figure 4. The effect of expression of dominant-negative RhoA on proliferation and cell-cycle progression. (A) [3H] Thymidine uptake of ckit+ cells expressing dominant-negative RhoA; control (▪), RhoAN19 (□). Data represent the mean ± SEM of 3 independent experiments, *P < .01 versus control group. (B-E) Flow cytometric analysis of cell-cycle status of transduced ckit+ cells. (B-C) Cells expressing the control virus. (D-E) Cells expressing RhoAN19. (C,E) Cells stimulated with SCF for 9 hours. The percentage of cells in each phase of cell cycle is shown at upper right. Data are representative of 4 independent experiments. *P < .05 versus control group.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/108/6/10.1182_blood-2006-02-001560/4/zh80180601410004.jpeg?Expires=1736042958&Signature=bffP8v51Dg5Bsa96hOmHb2aoaIETPvkBrsdN~lw1UNuSwSFjKUckKX3MmULyNokL0NyFOQjEAXslfb532PpHidYOKvO0dpgHWsAMgyEh69jnpvUEdYNTqKw9uIK9q-BGxKZ2bwS6jzT1xFCxt~ujYQka-ClrL1tHg3ZbV0ZejoabVp2DRMt0ZkhiJvjC79deUb8DcanpFZ3Jv7mj8RUwpuZaMgD7nuI3cHeuvadQKIOm7R0nNYgUclfZoiW5Mp7oZOPN39S3qc7qRsIt~DdzfXenNI85uRf9-F1OHWlFJJaVZn3osN2OvOfpxSgpGdkmMns4PHjWVApy6SBO4sLKOQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The effect of expression of dominant-negative RhoA on proliferation and cell-cycle progression. (A) [3H] Thymidine uptake of ckit+ cells expressing dominant-negative RhoA; control (▪), RhoAN19 (□). Data represent the mean ± SEM of 3 independent experiments, *P < .01 versus control group. (B-E) Flow cytometric analysis of cell-cycle status of transduced ckit+ cells. (B-C) Cells expressing the control virus. (D-E) Cells expressing RhoAN19. (C,E) Cells stimulated with SCF for 9 hours. The percentage of cells in each phase of cell cycle is shown at upper right. Data are representative of 4 independent experiments. *P < .05 versus control group.
