Relative defects in bidirectional signaling conferred by β3 cytoplasmic tail mutations. A bar graph is used to show the relative change in soluble fibrinogen binding (a measure of inside-out signaling) versus that in spreading on immobilized fibrinogen (a measure of outside-in signaling) in platelets expressing each mutant β3 C-tail; n = 7 for each group; error bars indicate mean ± standard deviation.