Figure 1
Figure 1. Effects of COX-1 inhibition, TP blockade, or both on TxA2 and PGI2 biosynthesis in LDLR KO mice on a high-fat diet. (A) Whereas SC-560 treatment significantly suppressed, BM-573 only partially reduced urinary 2,3-dinor-TxB2 excretion. (B) Neither SC-560, nor BM-573, alone or in combination, had a significant effect on urinary 2,3-dinor-6-ketoPGF1α excretion. *P =.03 and **P < .01 versus placebo. Results are presented as mean ± SEM.

Effects of COX-1 inhibition, TP blockade, or both on TxA2 and PGI2 biosynthesis in LDLR KO mice on a high-fat diet. (A) Whereas SC-560 treatment significantly suppressed, BM-573 only partially reduced urinary 2,3-dinor-TxB2 excretion. (B) Neither SC-560, nor BM-573, alone or in combination, had a significant effect on urinary 2,3-dinor-6-ketoPGF1α excretion. *P =.03 and **P < .01 versus placebo. Results are presented as mean ± SEM.

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