American Society of Hematology

Figure 2

$Figure 2. Thermal denaturation studies of the WT and Q471P mutant. WT and Q471P recombinant spectrin fraction folded as a function of temperature based on (A) circular dichroism and (B) DSC measurements all show a significant thermal destabilization of the Q471P mutant relative to the WT construct at or below 37°C.$

Thermal denaturation studies of the WT and Q471P mutant. WT and Q471P recombinant spectrin fraction folded as a function of temperature based on (A) circular dichroism and (B) DSC measurements all show a significant thermal destabilization of the Q471P mutant relative to the WT construct at or below 37°C.

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