Qualitative classification of individual engraftment kinetics. (A) Shown are 87 previously published¹⁸  repopulation kinetics of mice transplanted with clonally derived HSC grafts obtained by in vitro or in vivo limiting dilution. Shaded areas illustrate early (light) and late (dark) repopulation phases. Whereas +/− indicate an increase or decrease in the engraftment levels of more than 10% between the first and the last measurement in the given period, π refers to a constant (ie, change of less than 10%) time progression. (B) Shown are 87 representative simulated engraftment kinetics according to the given classification scheme. Underlying model parameters d and f_α(Ñ) are randomly sampled from the best-fit region shown in Figure 4B.