Figure 1
Figure 1. Transient siderocytosis following Mx1-Cre–mediated Abcb7 gene deletion. (A) Serial peripheral blood siderocyte counts in 5 representative Abcb7fl+Mx1-Cre animals induced at 4 days of age. Iron-stained peripheral blood smears of Abcb7fl−Mx1-Cre (B) and Abcb7fl+Mx1-Cre (C) animals. Black arrows indicate cells with siderotic granules. Transmission electron micrographs of reticulocytes in Abcb7fl animals with or without Mx1-Cre (D) −Cre, conventional electron microscopy (EM) stain; (E) +Cre, conventional EM stain; (F) −Cre, EM Fe stain; (G) +Cre EM Fe stain. White arrows indicate a representative mitochondrion in each field. Note the increased electron density of the mitochondrial membranes in panel G. Electron micrographs: original magnification, ×24 000.

Transient siderocytosis following Mx1-Cre–mediated Abcb7 gene deletion. (A) Serial peripheral blood siderocyte counts in 5 representative Abcb7fl+Mx1-Cre animals induced at 4 days of age. Iron-stained peripheral blood smears of Abcb7fl−Mx1-Cre (B) and Abcb7fl+Mx1-Cre (C) animals. Black arrows indicate cells with siderotic granules. Transmission electron micrographs of reticulocytes in Abcb7fl animals with or without Mx1-Cre (D) −Cre, conventional electron microscopy (EM) stain; (E) +Cre, conventional EM stain; (F) −Cre, EM Fe stain; (G) +Cre EM Fe stain. White arrows indicate a representative mitochondrion in each field. Note the increased electron density of the mitochondrial membranes in panel G. Electron micrographs: original magnification, ×24 000.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal