Inhibition of the Wnt signaling by quercetin induces down-regulation of Wnt target genes and apoptosis of ALL cells. Expression of Wnt-signaling pathway genes before and after treatment with quercetin in TOM-1 (A) and NALM-20 (B) cell lines. Expression was normalized in comparison with healthy lymphocytes (Normalized ratio = 100%). The mean ± SD of 3 different experiments is shown. (C) Apoptosis of ALL cells was significantly higher after treatment with quercetin (P < .05). (D) Expression of PARP was increased after treatment with 5-aza-2′-deoxycytidine (Aza) and quercetin (Quer). A representative example of 3 experiments is shown.