Human CMPs give rise to cDCs and pDCs in NOD-scid/IL2rγ^null recipients.(A) Purification of human cord blood CMPs based on the expression of lineage antigens hCD34, hCD38, hIL-3Rα, and hCD45RA. (B) Myeloid progeny in the bone marrow 4 weeks after CMP xenotransplantation is shown. Mature hCD13⁺ granulocytes, hCD41a⁺ platelets, and hGPA⁺ erythroid cells were seen in the bone marrow. (C) CMP-derived cDCs and pDCs developed in both the bone marrow and the spleen of CMP recipients. Morphology of purified cDC and pDC progeny is also shown (May-Grünwald-Giemsa staining). See “Analysis of human cell engraftment” for complete image acquisition information. BM indicates bone marrow.