Human CLPs give rise to cDCs and pDCs in NOD-scid/IL2rγ^null recipients. (A) Purification of human cord blood CLPs based on the expression of lineage antigens hCD34, hCD38, and hCD7. (B) The analysis of recipients 4 weeks after CLP xenotransplantation. B- and NK-cell progeny and T-cell progeny were found in the spleen and the thymus, respectively. (C) hCD45⁺ human CLP progeny included cDCs and pDCs in both the bone marrow and the spleen. Morphology of purified cDC and pDC progeny is also shown (May-Grünwald-Giemsa staining). The pDC images presented in 3 separate boxes were taken from a single slide. See “Analysis of human cell engraftment” for complete image acquisition information. BM indicates bone marrow.