Mobilization of HPC in mice treated with GROβ or GROβΔ4 alone or in combination with G-CSF. (A) CFU-GM, CFU-GEMM, and CFU-Meg/2 × 106 PBMC graft mobilized with G-CSF, GROβ, GROβΔ4, or the combination of G-CSF plus either GROβ or GROβΔ4. Data are an average of 5 experiments for CFU-GM and 2 to 4 experiments for CFU-GEMM and CFU-Meg from 3 mice/group, each assayed individually. †Synergy compared with G-CSF or GROβ/GROβΔ4 (P < .05), as determined using ANOVA with Bonferroni multiple comparison test. (B) C-kit+, lineage− (KL) cells/2 × 106 PBMC graft mobilized by G-CSF, GROβΔ4 or the combination of G-CSF plus GROβΔ4. Data are expressed as mean (± SEM) from 6 replicates of 10 mice per group in 2 experiments. †Synergy compared with G-CSF or GROβΔ4, P < .05, determined using ANOVA with Bonferroni multiple comparison test.
