Frequency of submicroscopic bone marrow involvement at relapse diagnosis in the total cohort (n = 64). Quantitative levels of submicroscopic BM involvement at relapse diagnosis are shown for all patients. Twenty-eight percent (18/64) of patients have a disease level of lower than 10−4; 22% (14/64), equal to or higher than 10−4 and lower than 10−3; 34% (22/64), equal to or higher than 10−3 and lower than 10−2; and 16% (10/64), with levels equal to or higher than 10−2.