Hypereosinophilic mice show accelerated viral clearance in the lung. (A) WT (○) and hypereosinophilic (IL-5 Tg; ●) mice were inoculated with RSV at day 0 and viral clearance or (B) increases in numbers of mucus-secreting cells per 100 μm of airway epithelial basement membrane monitored at the times indicated. (C) Eosinophils (5 × 106 cells) isolated from hypereosinophilic mice were adoptively transferred to WT mice 2 hours prior to inoculation with RSV. Viral titer was determined at 6 dpi. Bars represent the median value. (D) WT or ΔdblGATA mice were inoculated with RSV and viral titer quantified at 5 dpi. Data represent the mean plus or minus SEM (n = 3-6 mice per experimental group). Bars represent the median value. *P < .05; **P < 0.01; ***P < .001.
