Schema of signaling pathways from the calcium-sensing receptor on B cells to NF-κB. The binding of Ca_o²⁺ to a cell surface receptor or receptors activates PLCγ and releases Ca_i²⁺ stores, leading to the activation of 3 main signaling cascades (PKC, AKT, and CaM) that converge on IKK and result in the activation and translocation of NF-κB. The signaling pathway activated by S28690 is also shown.