Comparison of angiotensin-II (Ang-II)–mediated leukocyte recruitment in arterioles and venules. In arterioles, high constitutive expression of IL-4 and Ang-II–induced TNF induces expression of CC chemokines such as MCP-1 and RANTES over a time course of several hours. These chemokines mediate selective arrest of mononuclear leukocytes in arterioles. In contrast, in postcapillary venules, Ang-II induces rolling and arrest within 60 minutes, predominantly recruiting neutrophils to the endothelial surface. This process does not require either IL-4 or TNF.