LRP-1 regulates expression of complement components. PEA-10, MEF-2, and B-41 cells were grown for 18 hours in SFM and then analyzed by qPCR to determine expression of (A) C1r, (B) C1s, and (C) C1INH. (D) PEA-10 and MEF-2 cells were grown in SFM for 18 hours in the presence of JSH-23 (10 μM), JNK inhibitor (10 μM), PD98059 (40 μM), or vehicle (DMSO). C1r expression was determined by qPCR. Error bars represent SD.