Cluster composition based on clinical stage. Entries are presented as: residual [no. observed | no. expected], where residual = (observed −expected) /sqrt (expected). Yellow indicates relative deficiency of cluster with respect to the clinical stage, and green indicates enrichment of cluster with respect to the clinical stage, comparing observed with expected composition. Sample phenotype correlation showed cluster 1 to be composed of a roughly equivalent proportion of clinical stages. However, this breakdown was statistically enriched with stage IIB, or tumor stage, disease and lacking in stage IB disease. Cluster 2 was enriched with patch/plaque stage disease, with only 2 samples categorized as stage IIB and III. Cluster 3 showed depletion in stage IA and IIB disease and enrichment in stage IB and III disease. These findings were statistically significant, with a P value of .004.