Platelets roll/translocate on stimulated endothelium of veins; this can lead to their firm adhesion. Endothelium either activated to release WPBs or inflamed by cytokines captures resting or activated platelets. These roll on the selectins or move laterally on VWF. In inflammation, fibrinogen or fibrin oligomers can promote firm adhesion of activated platelets by cross-linking the major platelet integrin to endothelial receptors. These adherent platelets expressing P-selectin may recruit leukocytes but may also initiate pathological thrombosis such as occurs in deep veins. The various known ligands and receptors participating in these platelet adhesion events are listed. Illustration by Marie Dauenheimer.