VWF mediates platelet adhesion at sites of vascular injury, and the metalloprotease ADAMTS13 limits thrombus growth cleaving VWF. Defects in VWF secretion or clearance are common causes of VWD type 1.

VWF mediates platelet adhesion at sites of vascular injury, and the metalloprotease ADAMTS13 limits thrombus growth cleaving VWF. Defects in VWF secretion or clearance are common causes of VWD type 1.

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