Figure 4
Contributions of CD25+ Treg cells to unresponsiveness of patients' T cells from peripheral blood and involved tissue samples. (A) Lack of T-cell proliferation in patients' samples, whereas control PBMC samples demonstrate significant proliferation with control stimuli PPD or DPT. (B) Increased proliferation to PPD by T cells from PBMCs and involved tissue samples after CD25+ cell depletion. (C) Increased T-cell proliferation on adding a blocking anti–CTLA-4 F(ab)2 fragment to patients' PBMC cultures stimulated by PPD or DPT.
