Mouse model of CNS Ph⁺ leukemia. (A) Diagram showing the injection sites. (B) Section from the brain of a mouse that had received trypan blue at the correct injection site. The white arrow indicates the trypan blue distributed in the bilateral cerebral ventricles. Brain (C) and spinal cord (D) taken from a mouse on day 16 after inoculation of 5 × 10⁴ Ba/F3/wt bcr-abl^GFP cells at the correct injection site. The dotted lines indicate the outline of the spinal cord. The data shown are representative of 3 independent experiments.