CsA increases the concentrations of INNO-406 in the CNS. Radioactivity (A) and concentration (B) of INNO-406 in the brains of mice that had been orally administered 30 mg [14C]INNO-406/kg with (○) or without (•) prior administration of 50 mg CsA/kg. Radioactivity (C) and concentration (D) of INNO-406 in the plasma of mice that had been orally administered 30 mg [14C]INNO-406/kg with (○) or without (•) 50 mg CsA/kg. Error bars indicate standard deviation.