Course and rate of CSF3R mutations in patients with CN. Plotted is the percentage of mutated clones at different times (age in years) for patients with CN. The different mutations are encoded by different colors, which correspond to Figure 1. (A) Patients who have not developed a malignancy so far (including patients who underwent HSCT). (B) Patients with secondary malignancies (*Data from Bernard et al³¹  and Ancliff et al³² ). (C) Rate of mutated clones at time of malignant transformation.