Figure 1
Abl protein with the activation loop in the closed configurations showing the manner in which imatinib (marked IM) occupies the ATP-binding site (also known as the phosphate- or P-loop). Note also the relative position of 3 of the more commonly mutated residues: (1) T315I in the gateway position, (2) E255K in the P-loop, and (3) H396P in the activation loop. Adapted with permission from Deininger et al.5 © The American Society of Hematology.
