Normal IL-1β secretion in p22^phox and Nox2-deficient patients. (A) Peripheral blood of p22^phox patients and controls was diluted 1:10 and cultured overnight in the presence of uric acid (100 μg/mL), silica (100 μg/mL), imiquimod (10 μg/mL), or LPS (10 μg/mL). (B) PBMCs from Nox2-deficient patients (patients 3 and 4), a p47^phox-deficient patient (patient 5), and a control were cultured overnight in the presence of uric acid (100 μg/mL) or silica (100 μg/mL).