Figure 1
Figure 1. GWA study of serum MCP-1. (A) Signal-intensity plot showing the age- and sex-adjusted association of SNPs across all autosomes with MCP-1 in the GWA analysis. The coordinate provides the number of the chromosome. Lines indicate P value thresholds for P = 5 * 10−8. (B) Regional plots of associations with lowest P value for the DARC gene. Based on HapMapCEU, NCBI Build 36. The color coding represents r2 with lead SNP (rs12075), white indicates r2 < 0.01; gray, 0.01 ≤ r2 < 0.1; yellow, 0.1 ≤ r2 < 0.2; orange, 0.2 ≤ r2 < 0.5. Signal intensity for multivariable-adjusted serum concentrations and results for plasma are presented in supplemental Figure 2.

GWA study of serum MCP-1. (A) Signal-intensity plot showing the age- and sex-adjusted association of SNPs across all autosomes with MCP-1 in the GWA analysis. The coordinate provides the number of the chromosome. Lines indicate P value thresholds for P = 5 * 10−8. (B) Regional plots of associations with lowest P value for the DARC gene. Based on HapMapCEU, NCBI Build 36. The color coding represents r2 with lead SNP (rs12075), white indicates r2 < 0.01; gray, 0.01 ≤ r2 < 0.1; yellow, 0.1 ≤ r2 < 0.2; orange, 0.2 ≤ r2 < 0.5. Signal intensity for multivariable-adjusted serum concentrations and results for plasma are presented in supplemental Figure 2.

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