Motor performance. (A) The sum strength in forelimbs and hind limbs was measured more than 150 days after transplantation (range, 158-316 days; WT: n = 6; average age, 208 days; range, 167-252 days; LV-SF-GFP: n = 13; average age, 210 days; range, 158-316 days; LV-SF-GAA: n = 22; average age, 212 days; range, 158-316 days). Congenic age-matched WT animals are stronger than both Gaa^−/− mice that received a transplant of LV-SF-GFP or with LV-SF-GAA, and the mice that received a transplant of LV-SF-GAA are significantly stronger than the LV-SF-GFP mice (**P < .01; ***P < .001). (B) Rotarod performance. The latency (seconds on the rotarod) was determined in all treatment groups at the age of 10 months (WT, n = 6; LV-SF-GFP, n = 10; LV-SF-GAA, n = 14). WT mice perform significantly better (P < .05) than animals that received a transplant of LV-SF-GFP. Mice that received a transplant of LV-SF-GAA perform on average better than animals that received a transplant of LV-SF-GFP (not significant) but worse than WT animals (not significant). (C) Running wheel performance. Running distances increased during the 11 days that they were measured (WT, n = 3; LV-SF-GFP, n = 5; LV-SF-GAA, n = 6). WT mice run longer distances than both mice that received a transplant of LV-SF-GFP (**P < .01) and mice that received a transplant of LV-SF-GAA, and mice that received a transplant of LV-SF-GAA mice perform better than animals that received a transplant of LV-SF-GFP (*P < .02).