Memory cells constitutively expressing CD62L do not cause severe GVHD. On day 0, BALB/c recipients received 800 cGy and 107 BM cells from CD45.1 B6 donors with or without 3 × 105 naive or memory cells from control transgenic (metalloproteinase site intact, Ctrl Tgic) or LΔP donors. Shown are combined data from 3 experiments with sort-purified cells as described in the Figure 5 legend. (A) Weight curve. †P < .05 for BM controls versus Ctrl Tgic naive or LΔP naive for all days 6 and later; @P < .05 for BM controls versus Ctrl Tgic memory or LΔP memory for all days 17 and later. (B) Survival curve. NS indicates not significant for BM controls versus WT memory or LΔP memory and for WT memory versus LΔP memory; †P < .0001 for BM controls versus Ctrl Tgic naive or LΔP naive.
