Figure 1
![Figure 1. Toxicity profiles of gossypol versus apogossypol in normal mice. Female Balb/c mice (7 weeks old) (n = 6 per group) were orally administered vehicle control (■), 120 μmol/kg gossypol (•), or 120 μmol/kg apogossypol (♦) 5 times weekly for 3 weeks. (A) Percentage survival of mice is shown over time. (B) Body weight is shown over time, in grams (mean ± standard deviation [SD]). Data are representative of several experiments involving a total of 20 gossypol-treated, 40 apogossypol-treated, and 20 vehicle control–treated mice.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/111/6/10.1182_blood-2007-09-113647/6/zh80060817090001.jpeg?Expires=1735595183&Signature=wrKHdsGU-fWCZ3vIU01lWBJWBM6uud-lW39KKtdcT~uXmvfIDDctC~4w1WV3vLPymdzJ7cP-eF-Lg7BotNYTZ-TfWVzJy2hjKuXOK~DL48f3VrfuxT-NBa80FiksEcq3S2dDkfla7HMr5YxSVZeFie28MOdgtrCQ4R5h8YcEDc0shkFLhPY4JT~GQKNhd6GQazSCREuEUGMYxo8SxxrpBaZmJ0YWk84QUrtTkz-mJLHBizEIyK71mNWOstqMgh7JGPKvo0eCf-aeq7RVk9UQpRMikcFDYekBZdjK6-e3EpG4o8Nxyycpq4ygaOXX-qb2Szoc966qTHTTKTUP2hsO2A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Toxicity profiles of gossypol versus apogossypol in normal mice. Female Balb/c mice (7 weeks old) (n = 6 per group) were orally administered vehicle control (■), 120 μmol/kg gossypol (•), or 120 μmol/kg apogossypol (♦) 5 times weekly for 3 weeks. (A) Percentage survival of mice is shown over time. (B) Body weight is shown over time, in grams (mean ± standard deviation [SD]). Data are representative of several experiments involving a total of 20 gossypol-treated, 40 apogossypol-treated, and 20 vehicle control–treated mice.
