Gene expression profiles of 92 T-ALL patients. (A) Differentially expressed genes among the major molecular cytogenetic T-ALL subgroups (TAL1, LMO2, HOXA, HOX11/TLX1, and HOX11L2/TLX3; n = 67). The significance level (Wilcoxon P value) and FDR corrected P value for the top 100 genes in each T-ALL subgroup is indicated. TAL1, HOX11, and HOX11L2 subgroups show significant differentially expressedprobesets. (B) Cluster analysis of 92 patients with T-ALL (67 with known, 25 with unknown) based upon the top 25 most significant probesets for the TAL1, TAL1/LMO2, HOX11, and HOX11L2 subgroups combined with 15 HOXA probesets as previously described.8 (C) Principal component analyses shows clustering of the patients with unknown T-ALL along the molecular cytogenetic known patients: 1 HOX11L2-like, 19 TAL1/LMO2-like, and 5 HOXA-like patients.
