Figure 4
Figure 4. Results of sequencing of IGH gene rearrangements or JH/BCL2 breakpoint regions. All of the sequences are arranged with the specimen sequence at the top, compared with the lower IMGT gene bank sequence. The dashes indicate the sequence is identical to the gene bank sequence, and the nucleotides indicate areas where they differ. Illustrated are cases 1 and 4 (Fr2) and cases 2 and 5 (Fr 3). While the FL and H/DC paired samples from case 2 are similar, the H/DC tumor biopsied 12 years after the FL demonstrates additional mutations. Sequencing of BCL2/JH breakpoint region obtained with MBR probe is illustrated in case 8.

Results of sequencing of IGH gene rearrangements or JH/BCL2 breakpoint regions. All of the sequences are arranged with the specimen sequence at the top, compared with the lower IMGT gene bank sequence. The dashes indicate the sequence is identical to the gene bank sequence, and the nucleotides indicate areas where they differ. Illustrated are cases 1 and 4 (Fr2) and cases 2 and 5 (Fr 3). While the FL and H/DC paired samples from case 2 are similar, the H/DC tumor biopsied 12 years after the FL demonstrates additional mutations. Sequencing of BCL2/JH breakpoint region obtained with MBR probe is illustrated in case 8.

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