c-Abl is required for chemokine-induced T-cell migration. (A) Jurkat T cells were transfected with control vector or shAbl-3, and migration in response to CXCL12 stimulation was tested using a Transwell assay. (B) Lymph node CD4⁺ T cells were prepared from abl^flox/floxCD4-Cre⁺ mice and control littermates, and migration in response to CXCL12 or CCL21 was tested using a Transwell assay. In each case, representative data (averages of quadruplicate samples plus or minus 1 SD) from one of 3 independent experiments are shown. **P < .01; *P < .05.