KSHV-positive cells in primary cases of PEL, KS, and MCD exhibit decreased levels of TβRII. (A) Double immunohistochemical staining for TβRII and LANA in a cell clot containing a 1:1 mixture of BC3 cells (black arrow) and Ramos cells (white arrow), (B) a primary PEL specimen cell clot containing neoplastic (black arrow) and reactive (white arrow) cells, (C) a MCD tissue section, and (D) a KS tissue section. LANA positivity appears as brown nuclear staining and TβRII appears red at the membrane and in the cytoplasm. Black arrows indicate LANA⁺, TβRII⁻ cell; white arrow, LANA⁻, TβRII⁺ cell; blue arrow, LANA⁺, TβRII⁺ cell (original magnification ×132)