Lack of mannose receptor alters the behavior of B16 melanoma. (A) Representative examples of mice after subcutaneous injections of B16 melanoma cells bearing the luciferase-containing construct into the ears. Arrows point to the signals from the primary tumors (white) and metastatic foci (yellow) in the neck lymph nodes. (B) The size of the primary tumors during the 14-day follow-up measured based on the luciferase signals. (C) The size of the lymph node metastases at the end of the experiment. (D) The ratios between the lymph node metastases and primary tumors of WT and MR^−/− mice. (E) Total luciferase counts of primary tumor and lymph node metastases in MR^−/− and WT mice at the end of the experiments (14 days). All values shown are means (± SEM).