American Society of Hematology

Figure 3

$Figure 3. Expression of selected gene sets. (A) Expression of a set of 244 ECM and adhesion-related genes that distinguish PCNSL from non-CNS DLBCL. LOWESS normalization was performed using genes present on at least 35 of the 43 arrays. The colored points are normalized gene ratios for these approximately 11 500 genes, whereas the black points are the ECM and adhesion-related genes. (B) Expression of a set of 92 cytokine genes that distinguish PCNSL and nodal DLBCL. LOWESS normalization was performed using genes present on at least 35 of the 43 arrays. The colored points are normalized gene ratios for these approximately 11 500 genes, whereas the black points are the cytokine-related genes. (C) Expression of a set of 159 apoptosis-related genes that distinguish PCNSL from extranodal DLBCL. LOWESS normalization was performed using genes present on at least 35 of the 43 arrays. The colored points are normalized gene ratios for these approximately 11 500 genes, whereas the black points are the apoptosis-related genes. The range of colors in these panels reflects range of gene levels in the CNS phenotype in panel A, or the Nodal and Extranodal phenotype in panels B and C, respectively. Specifically, the gene level refers to the ratio formed by dividing the gene level in the tumor by the level of the universal reference. Red indicates levels more than 1.0, whereas green indicates fractions less than 1.0.$

Expression of selected gene sets. (A) Expression of a set of 244 ECM and adhesion-related genes that distinguish PCNSL from non-CNS DLBCL. LOWESS normalization was performed using genes present on at least 35 of the 43 arrays. The colored points are normalized gene ratios for these approximately 11 500 genes, whereas the black points are the ECM and adhesion-related genes. (B) Expression of a set of 92 cytokine genes that distinguish PCNSL and nodal DLBCL. LOWESS normalization was performed using genes present on at least 35 of the 43 arrays. The colored points are normalized gene ratios for these approximately 11 500 genes, whereas the black points are the cytokine-related genes. (C) Expression of a set of 159 apoptosis-related genes that distinguish PCNSL from extranodal DLBCL. LOWESS normalization was performed using genes present on at least 35 of the 43 arrays. The colored points are normalized gene ratios for these approximately 11 500 genes, whereas the black points are the apoptosis-related genes. The range of colors in these panels reflects range of gene levels in the CNS phenotype in panel A, or the Nodal and Extranodal phenotype in panels B and C, respectively. Specifically, the gene level refers to the ratio formed by dividing the gene level in the tumor by the level of the universal reference. Red indicates levels more than 1.0, whereas green indicates fractions less than 1.0.

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