CD4 T-cell counts from 39 ICL subjects during follow-up. Individual CD4 trajectories are shown for 5 subjects whose median CD4 T-cell count among those with at least 2 years of follow-up and 4 measurements was the minimum, maximum, or an innerquartile trajectory. The average individual trend fitted from the linear mixed model is also shown (bold solid line). The slope (SD) of the estimated trend is 0.66/mm³ per month (95% confidence interval, −0.20-1.54).