Wnt3a prevents bone loss and reduces tumor burden in myelomatous bones. SCID-hu mice were engrafted with H929/EV or H929/W3A cells. (A) X-ray radiographs of the implanted myelomatous bones taken from 3 representative mice in each group, before cell engraftment (Pre-MM) and at the experiment's end (MM). Note that, although EV-bearing bones were severely resorbed and tumors grew on the outer surface of the implanted bone, implanted bone mass from the H929/W3A-bearing hosts was preserved. (B) Changes in the level of BMD of implanted bones engrafted with H929/EV or H929/W3A cells. (C) Circulating human Ig level of SCID-hu mice engrafted with H929/EV or H929/W3A cells. Error bars represent SEM.