Steady-state imatinib trough levels in chronic-phase CML patients who did and did not achieve CCyR. The mean plasma imatinib trough levels were 1009 plus or minus 544 ng/mL (median, 909 ng/mL) and 812 plus or minus 409 ng/mL (median, 757 ng/mL) for patients who did (n = 297) or did not achieve CCyR (n = 54) during study, respectively (P = .01, t test; P = .004, Wilcoxon test). The figure shows boxplots of C_min (trough levels) with top and bottom walls of each box representing the 75th and 25th percentiles, respectively. Whiskers above and below the box extend to the 90th and 10th percentiles, respectively, and the dots represent 95th and 5th percentiles.