Estimated cumulative CCyR and MMR rates by PK category of steady-state imatinib trough levels. (A) The estimated cumulative CCyR rates in the 351 patients with available imatinib trough levels at steady state. CCyR rates were significantly lower during the 5-year period for patients in the lowest PK category (Q1 vs others, P = .005, and P = .01 overall). (B) Estimated MMR rates in 265 patients who achieved a CCyR, and for whom PCR data as well as PK samples were available. Among patients with CCyR, lower MMR rates significantly correlated with the lowest imatinib trough levels (Q1 vs others, P = .008, and P = .02 overall).