Figure 1
Effect of TTP plasma and TRAIL on survival of HUVECs and pulmonary and dermal MVECs. ECs were exposed to control plasma (1% vol/vol), acute TTP plasma (1% vol/vol), or varying concentrations of recombinant TRAIL for 18 hours. The extent of apoptosis was quantitated by propidium iodide–based DNA histogram analysis and measurement of hypodiploid A0 peaks. There was no difference in apoptosis of HUVECs or pulmonary MVECs in the presence of control versus TTP plasma, while TTP plasma induced apoptosis in the dermal MVECs (P < .007). Standard deviations are noted for mean values for control and TTP plasma.
