Immunohistochemistry showing localization of infused, recombinant bovine MAGP1 at the site of vascular injury. (A) Photomicrographs on the left are cross sections of carotid arteries from MAGP1+/+ and MAGP1−/− mice infused with 50 μg/kg recombinant bovine MAGP1 5 minutes prior to laser-induced injury. Vessels were harvested after complete cessation of blood flow and frozen sections immunostained using a bovine MAGP1-specific antibody. Staining is evident in the thrombus of both genotypes but is particularly prominent in the internal elastic lamina in the MAGP1−/− mouse (↗, and at higher power in panel B). Panels on the right show staining with antibovine MAGP1 of injured vessels from animals not injected with bovine MAGP1.