Decrease of 8972-Da peak after CsA administration in GVHD mice. (A) Representative SELDI spectra of control plasma (day 0; before transplantation) and GVHD plasma (days 7, 14, 21, and 28 after transplantation) from the same mouse. The m/z range of 6000 to 10 000 m/z is shown. CsA was administered from day 8 through day 13 after transplantation, indicated by closed triangle. The box highlights a plasma peak with an average mass of 8972 Da that decreased after administration of CsA. The peak intensity of 8972 Da is 5.8, 69.4, 13.8, 15.7, and 14.3 on days 0, 7, 14, 21, and 28, respectively. (B) Mean normalized intensity for the 8972-Da peak in the samples on days 0 (before transplantation), 7, 14, 21, and 28 (n = 6, respectively). The average intensity (± SE) is depicted (n = 6). The 8972-Da peak seen at day 7 significantly decreased at days 14, 21, and 28 (paired t test). The peak at day 7 is significantly higher than that of day 0 (before transplantation) (paired t test). Asterisk indicates P value.