Cul4A loss causes a decline in peripheral blood hematopoietic cells. Mutant (■) and controls (□) were induced with pIpC, and peripheral blood counts were determined and plotted versus days after induction. For panel D, lymphocyte counts were normalized to the counts on day 0. Asterisks denote time points where mutant and control count differences were statistically significant (P ≤ .03). Results from 6 independent experiments were combined.