Treatment schemes for the 2 arms of the GITMO/IIL trial. Plain solid lines indicate drugs delivered to all patients with FL. Dotted lines show drugs delivered only in specific cases: DHAP in patients where there was a lack of CR after APO, and 2 additional rituximab in patients with PR or PCR positivity at the end of treatment. A single APO course consisted of doxorubicin (75 mg/m²) on days 1 and 22, vincristine (1.2 mg/m²) on days 1 and 15, and prednisone (50 mg/m²) on days 1 to 22. The DHAP course consisted of cisplatin (100 mg/m²) on day 1, Ara-C (4 g/m²) on day 2, and dexamethasone (40 mg) on days 1 to 4. hd-VP16 indicates high-dose etoposide; hd-Cy, high-dose cyclophosphamide; PBSC, peripheral blood stem cell collection; and MITO/L-PAM, mitoxantrone plus melphalan.