Peripheral white blood cell counts of mice/D171N showed leukocytosis, while mice/S291fs showed leukocytopenia. (A) Counts of white blood cells (WBCs) in PB. (B) Concentration of hemoglobin (Hg). (C) Counts of platelets (PLT). (D) Red cell MCV. (E,F) Weight of spleen and liver of morbid mice (mice/D171N or S291fs) or 1-year-old healthy mice (mice/WT or mock). Statistical differences were determined by 2-sample t test with Welch correction (*P < .05; **P < .01). Lane 1: mice/D171N without high expression of Evi1 in BM or not examined due to the lack of bone marrow samples (WBC, PLT, Hg, and MCV: n = 11; spleen: n = 5; and liver: n = 4). Lane 2: mice/D171N with high expression of Evi1 (n = 11). Lane 3: mice/S291fs (WBC, PLT, Hg, and MCV: n = 9; spleen and liver: n = 8). Lane 4: mice/WT (WBC, PLT, Hg, and MCV: n = 10; spleen and liver: n = 4). Lane 5: mice/mock (WBC, PLT, Hg, and MCV: n = 12; spleen: n = 6; and liver: n = 5).