Multilineage dysplasia of hematopoietic cells in mice that received transplants of AML1 mutants. Giemsa-stained PB smears obtained from mice/D171N or S291fs are shown. (A) Howell-Jolly body, polychromasia, and anisopoikilocytosis. (B) Orthochromatic giant erythroblast, karyorrhexis, and nuclear fragments. (C) Pseudo-Pelger-Huet anomaly. (D) Hypersegmented neutrophil. (E) Blasts in peripheral blood. (F) Giant platelet. Images were obtained with a BH51 microscope and DP12 camera (Olympus, Tokyo, Japan); objective lens, UPlanFl (Olympus); magnification, ×1000.