Microarray analysis of APECED and control monocytes and monocyte-derived DCs. (A) The gene expression profiles (log2 of fold change between APECED patient A8 and control 2) of 61 differentially expressed ISGs in monocytes, iDCs, and mDCs. Most of the ISGs lost their differential expression by the iDC stage. (B) The differential expression of ISGs in APECED patient monocytes, iDCs, and mDCs. n indicates the total number of genes down-regulated 1.5-fold in each microarray data set. ISGs and non-ISGs indicate the number of genes, respectively, characterized or not characterized as ISGs. The expected numbers of ISGs and non-ISGs were calculated assuming the random selection. χ2 test was used to calculate the P values to determine whether the deviation is significant.
